Endocrine Abstracts

Background: Despite good prognosis patients with previously treated well-differentiated thyroid cancer (DTC) require lifelong monitoring for recurrent disease. The diagnostic value of radioiodine whole body scanning and serum thyroglobulin (Tg) measurement is most accurate during thyroid stimulating hormone (TSH) stimulation. The introduction of recombinant human TSH (rhTSH)-stimulated testing offers the possibility to avoid hormone withdrawal associated with the morbidity of ...

Introduction: Coexistence of autoimmune thyroiditis (AIT) and papillary thyroid cancer (PTC) has been well documented, but causality is still a matter of debate. Pathogenetic links between PTC and AIT try to explain two theories: 1) PTC is induced or facilitated by AIT, 2) AIT is a response to PTC. It is believed that PTC associated to AIT has a better prognosis.Aims: To find out: 1) the incidence of AIT in PTC patients, 2) the course of PTC associated t...

Introduction: Nuclear retinoid receptors (RARs) upon a ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as heterodimers with nuclear retinoid X (rexinoid) receptors (RXRs). The disruption of retinoic acid (RA) signalling pathways is believed to underlie the etiology of a number of malignancies. Retinoids – cell differentiation agents that may ‘reprogram’ tumours, i.e. retinoic acid derivatives or retinoic acid related com...

Retinoid receptors (RARs) upon a proper ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as heterodimers with retinoid X receptors (RXRs). Predominantly, novel synthetic retinoid analogues acting through RARs as redifferentiation agents would be of great value in treating patients with advanced thyroid cancer.The objective of this study was to investigate all-trans retinoic acid/9-cis retinoic acid n...

Acromegaly is usually diagnosed after several years of duration. The multimodal therapy – surgery, radiotherpy, pharmacotherapy – is necessary in the majority of patients. Register of sellar tumors (RESET) collecting data of patients from eight tertiary centers in the Czech and Slovak Republics since the year 2000 was established in 2008.Aim of analysis: Evaluation of diagnostics of acromegaly and effectiveness of its treatment in a daily pract...